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KRAS-Centred Network Analysis Prioritises Indirect Targets and Literature-Supported Drug-Repurposing Candidates

2026-07-20

Abstract excerpt

Direct pharmacological inhibition of KRAS remains constrained by mutation specificity, tumour heterogeneity and the emergence of resistance, motivating complementary strategies that target proteins associated with KRAS signalling. Here, we constructed a human KRAS-centred protein-association network and integrated network topology, functional enrichment, genomic-location analysis and target-level curation of appro...

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Literature Corpus work
ef2654da-9df1-5dc9-835c-52c76b2fce62
DOI
10.20944/preprints202607.1430.v1
Open publication

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KRAS-Centred Network Analysis Prioritises Indirect Targets and Literature-Supported Drug-Repurposing CandidatesDOI 10.20944/preprints202607.1430.v1
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