Article
Maternal Phytosterol Supplementation during Pregnancy and Lactation Modulates Lipid and Lipoprotein Response in Offspring of apoE-Deficient Mice.
The Journal of nutrition - 1 Aug 2015
Rideout Todd C, Movsesian Cheryl, Tsai Yi-Ting, Iqbal Aadil, Raslawsky Amy, Patel Mulchand S
Abstract excerpt
BACKGROUND: In utero exposure to excessive cholesterol has been shown to increase fetal plasma cholesterol concentration and predispose adult offspring to cardiovascular disease (CVD) risk. Because lipid-lowering drugs are contraindicated during pregnancy, natural cholesterol-lowering compounds may be a safe and effective alternative to reduce CVD risk in offspring born to hypercholesterolemic mothers. OBJECTIVE:...
Topics
- Animals
- Apolipoproteins E
- Dietary Supplements
- Female
- Gene Expression Regulation
- Genetic Predisposition to Disease
- Hypercholesterolemia
- Lactation
- Lipid Metabolism
- Lipoproteins
- Maternal Nutritional Physiological Phenomena
- Mice
- Mice, Knockout