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Article

Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2017

Trenteseaux Charlotte, Gaston Anh-Thu, Aguesse Audrey, Poupeau Guillaume, de Coppet Pierre, Andriantsitohaina Ramaroson, Laschet Jamila, Amarger Valérie, Krempf Michel, Nobecourt-Dupuy Estelle, Ouguerram Khadija

Abstract excerpt

OBJECTIVE: Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E-deficient mice and the underlying mechanism. APPROACH AND RESULTS: Atherosclerosis and related parameters were studied in adult male...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28935756
DOI: 10.1161/ATVBAHA.117.309923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.PMID 28935756Read ↗

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