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Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? A Comparison of UV Mutational Signatures in Malignant Melanoma and Mycosis Fungoides.

Cells - 13 Jun 2023

Gniadecki Robert, O'Keefe Sandra, Hennessey Dylan, Iyer Aishwarya

Abstract excerpt

Ultraviolet (UV) radiation is a strong environmental carcinogen responsible for the pathogenesis of most skin cancers, including malignant melanoma (MM) and non-melanoma (keratinocyte) skin cancers. The carcinogenic role of UV was firmly established based on epidemiological evidence and molecular findings of the characteristic mutation signatures which occur during the excision repair of cyclobutane pyrimidine...

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Identifiers

PMID: 37371087
DOI: 10.3390/cells12121616
PMCID: PMC10297369

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