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Article

The MUC1 mucin protects against <i>Helicobacter pylori</i> pathogenesis in mice by regulation of the NLRP3 inflammasome

8 Apr 2015

Abstract excerpt

OBJECTIVES: The mucin MUC1, best known for providing an epithelial barrier, is an important protective host factor in both humans and mice during Helicobacter pylori pathogenesis. This study aimed to identify the long-term consequences of MUC1 deficiency on H. pylori pathogenesis and the mechanism by which MUC1 protects against H. pylori gastritis. DESIGN: Wildtype and Muc1(-/-) mice were infected for up to 9...

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Identifiers

PMID: 26079943
DOI: 10.1136/gutjnl-2014-307175

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