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Article

Olfactomedin 4 down-regulates innate immunity against <i>Helicobacter pylori</i> infection

1 Jun 2010

Abstract excerpt

Olfactomedin 4 (OLFM4) is a glycoprotein that has been found to be up-regulated in inflammatory bowel diseases and Helicobacter pylori infected patients. However, its role in biological processes such as inflammation or other immune response is not known. In this study, we generated OLFM4 KO mice to investigate potential role(s) of OLFM4 in gastric mucosal responses to H. pylori infection. H. pylori colonization...

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PMID: 20534456
DOI: 10.1073/pnas.1001269107

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