Article

The MUC1 extracellular domain and cytoplasmic tail play distinct roles during <i>Salmonella</i> invasion of enterocytes

2025-10-15

Abstract excerpt

The intestinal mucus layer consists of secreted and transmembrane (TM) mucins expressed on the apical surface of enterocytes. The TM mucin MUC1 has a highly O-glycosylated extracellular domain (ED) and a cytoplasmic tail (CT) with signaling potential. MUC1 is a target for the Salmonella adhesin SiiE, which mediates apical invasion of the bacterium into enterocytes. Here, we determined the contributions of the MUC...

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Literature Corpus work: 84f37c8b-ef27-57dc-a5e9-7f9ebaafeb7e
DOI: 10.1101/2025.10.15.682509

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