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Article

Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Emerging infectious diseases - 1 Jul 2015

Hawkes Michael, Conroy Andrea L, Opoka Robert O, Namasopo Sophie, Zhong Kathleen, Liles W Conrad, John Chandy C, Kain Kevin C

Abstract excerpt

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

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Identifiers

PMID: 26079933
DOI: 10.3201/eid2107.150213
PMCID: PMC4480400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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