Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous L1-deficient mice express an autism-like phenotype.

Behavioural brain research - 1 Oct 2015

Sauce Bruno, Wass Christopher, Netrakanti Meera, Saylor Joshua, Schachner Melitta, Matzel Louis D

Abstract excerpt

The L1CAM (L1) gene encodes a cell adhesion molecule that contributes to several important processes in the developing and adult nervous system, including neuronal migration, survival, and plasticity. In humans and mice, mutations in the X chromosome-linked gene L1 cause severe neurological defects in males. L1 heterozygous female mice with one functional copy of the L1 gene show complex morphological features...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anxiety
Share to Autistic Disorder
Share to Behavior, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Motor Activity

Share to Neural Cell Adhesion Molecule L1

Share to Social Behavior

Share to Stress, Psychological

Source

Identifiers

PMID: 26079769
DOI: 10.1016/j.bbr.2015.05.040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous L1-deficient mice express an autism-like phenotype.PMID 26079769Read ↗

Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities.Semantic proximity Read ↗

Heterozygosity for the mutated X-chromosome-linked L1 cell adhesion molecule gene leads to increased numbers of neurons and enhanced metabolism in the forebrain of female carrier mice.Semantic proximity Read ↗

Complex, multimodal behavioral profile of the <i>Homer1 </i>knockout mouseSemantic proximity Read ↗

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.Semantic proximity Read ↗

The Impact of Mild Chronic Stress and Maternal Experience in the Fmr1 Mouse Model of Fragile X SyndromeSemantic proximity Read ↗

Behavioral phenotypes of genetic mouse models of autism.Semantic proximity Read ↗

Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty.Semantic proximity Read ↗

Amelioration of the abnormal phenotype of a new L1 syndrome mouse mutation with L1 mimetics.Semantic proximity Read ↗

Characterization of Social and Repetitive Behaviors of Mllt11/Af1q/TcF7c Conditional Knockout MiceSemantic proximity Read ↗

Sociability and motor functions in Shank1 mutant mice.Semantic proximity Read ↗

Impaired learning and motor behavior in heterozygous Pafah1b1 (Lis1) mutant mice.Semantic proximity Read ↗

High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.