Article
PON1 polymorphisms are predictors of ability to attain HDL-C goals in statin-treated patients.
Clinical biochemistry - 1 Nov 2015
de Souza Jéssica Aguiar, Menin Angelica, Lima Luciana Otero, Smiderle Lisiane, Hutz Mara Helena, Van Der Sand Cézar Roberto, Van Der Sand Luiz Carlos, Ferreira Maria Elvira Wagner, Pires Renan Canibal, Almeida Silvana, Fiegenbaum Marilu
Abstract excerpt
OBJECTIVES: PON1 plays an important role in inhibiting LDL-C oxidation, which reduces atherosclerosis and cardiovascular disease. Elevated PON1 activity or levels may contribute to increased HDL-C levels, but controversy exists over the hypothesis that genetic variation in the PON1 gene locus modulates HDL-C levels and responses to statin treatment. Therefore, the objective of this study was to investigate the...
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