Article
The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia.
Journal of internal medicine - 1 Nov 2005
Himbergen T M, van Tits L J H, Voorbij H A M, de Graaf J, Stalenhoef A F H, Roest M
Abstract excerpt
OBJECTIVES: Statins reduce low-density lipoprotein cholesterol (LDL-C) and can raise high-density lipoprotein cholesterol (HDL-C). HDL-bound paraoxonase-1 (PON1) is associated with variations in plasma HDL-C, and may, therefore, contribute to changes of HDL-C during statin therapy. DESIGN: The effects of baseline PON1 status to HDL-C changes because of statin therapy were investigated. PON1 status was determined...
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