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Article

Hereditary ovarian cancer: not only BRCA 1 and 2 genes.

BioMed research international - 1 Jan 2015

Toss Angela, Tomasello Chiara, Razzaboni Elisabetta, Contu Giannina, Grandi Giovanni, Cagnacci Angelo, Schilder Russell J, Cortesi Laura

Abstract excerpt

More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65-85% of these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26075229
DOI: 10.1155/2015/341723
PMCID: PMC4449870

Genes

BRIP1
CHEK2
PALB2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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