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Article

Adaptive mutation PB2 D701N promotes nuclear import of influenza vRNPs in mammalian cells.

European journal of cell biology - 1 Jan 2000

Sediri Hanna, Schwalm Folker, Gabriel Gülsah, Klenk Hans-Dieter

Abstract excerpt

The segmented genome of influenza viruses is translocated into the nucleus to initiate transcription and replication. The gene segments are present as viral ribonucleoprotein (vRNP) particles composed of RNA, multiple copies of the nucleoprotein (NP), and the polymerase subunits PB1, PB2 and PA. The PB2 subunit and each NP monomer contain a nuclear localisation signal (NLS) that binds to importin-α. To throw...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26074198
DOI: 10.1016/j.ejcb.2015.05.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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