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Article

The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication.

PloS one - 1 Jan 2008

Resa-Infante Patricia, Jorba Núria, Zamarreño Noelia, Fernández Yolanda, Juárez Silvia, Ortín Juan

Abstract excerpt

The influenza virus polymerase is formed by the PB1, PB2 and PA subunits and is required for virus transcription and replication in the nucleus of infected cells. As PB2 is a relevant host-range determinant we expressed a TAP-tagged PB2 in human cells and isolated intracellular complexes. Alpha-importin was identified as a PB2-associated factor by proteomic analyses. To study the relevance of this interaction for...

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PMID: 19066626
DOI: 10.1371/journal.pone.0003904
PMCID: PMC2588535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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