Article
EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma.
Aging - 3 Dec 2020
Chen Zhiming, Chen Ji, Ren Dandan, Zhang Jiao, Yang Ying, Zhang Henghui, Mao Beibei, Ma Haitao
Abstract excerpt
Eph receptors constitute the largest family of RTKs, and their associations with antitumor immunity and immunotherapy are largely unknown. By integrating genomic, transcriptomic and clinical data from cohorts in public databases, we identified EPHA5 as the most common mutated gene of Eph receptors in lung adenocarcinoma (LUAD). Moreover, compared with EPHA5 wild-type (WT) patients, EPHA5-mutant (Mut) patients...
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