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Article

Mutations of the EPHB6 receptor tyrosine kinase induce a pro-metastatic phenotype in non-small cell lung cancer.

PloS one - 1 Jan 2012

Bulk Etmar, Yu Jun, Hascher Antje, Koschmieder Steffen, Wiewrodt Rainer, Krug Utz, Timmermann Bernd, Marra Alessandro, Hillejan Ludger, Wiebe Karsten, Berdel Wolfgang E, Schwab Albrecht, Müller-Tidow Carsten

Abstract excerpt

Alterations of Eph receptor tyrosine kinases are frequent events in human cancers. Genetic variations of EPHB6 have been described but the functional outcome of these alterations is unknown. The current study was conducted to screen for the occurrence and to identify functional consequences of EPHB6 mutations in non-small cell lung cancer. Here, we sequenced the entire coding region of EPHB6 in 80 non-small cell...

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Identifiers

PMID: 23226491
DOI: 10.1371/journal.pone.0044591
PMCID: PMC3514309

Genes

EPHB6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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