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Article

Novel Grm6 Variant in a no b-wave (nob) Mouse Model: Phenotype Characterization and Gene Therapy.

Investigative ophthalmology & visual science - 2 Sept 2025

Lin Pei-Hsuan, Kang Eugene Yu-Chuan, Makrides Neoklis, Lee Winston, Tseng Yun-Ju, Wu Pei-Liang, Peregrin John, Sherman Emmet, Wang Jason Hunghsuan, Swayne Theresa C, Li Tai-De, Agosto Melina A, Sparrow Janet R, Zhang Xin, Tsang Stephen H, Wang Nan-Kai

Abstract excerpt

Purpose: To characterize a no b-wave (nob) mouse model of congenital stationary night blindness (CSNB) caused by a Grm6 variant that disrupts photoreceptor-to-bipolar cell signaling. Additionally, we aim to evaluate the efficacy of gene therapy in restoring visual function. Methods: The nob mouse was generated through selective breeding to regenerate the nob phenotype. Adeno-associated viruses encoding Grm6 and...

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Identifiers

PMID: 40923695
DOI: 10.1167/iovs.66.12.20
PMCID: PMC12425143

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