SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.

doi:10.1158/1078-0432.CCR-15-0157

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Article

SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2015

Zhang Xiaotun, Coleman Ilsa M, Brown Lisha G, True Lawrence D, Kollath Lori, Lucas Jared M, Lam Hung-Ming, Dumpit Ruth, Corey Eva, Chéry Lisly, Lakely Bryce, Higano Celestia S, Montgomery Bruce, Roudier Martine, Lange Paul H, Nelson Peter S, Vessella Robert L, Morrissey Colm

Abstract excerpt

PURPOSE: The neuroendocrine phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the neuroendocrine phenotype in CRPC. EXPERIMENTAL DESIGN: Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and prostate-specific antigen (PSA) was analyzed by IHC in 155 CRPC metastases from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26071481
DOI: 10.1158/1078-0432.CCR-15-0157
PMCID: PMC4609255

Genes

CHGA
SYP
REST
SRRM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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SRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer.PMID 26071481Read ↗

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