Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

1α, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferation

11 Jun 2015

Abstract excerpt

1α, 25-dihydroxyvitamin D3 (VD3), a secosteriod that has been explored as an anti-cancer agent, was also shown to promote cell survival. Its receptor, the Vitamin D Receptor (VDR), is a direct target of the proto-oncogene ΔNp63α, which is overexpressed in non-melanoma skin cancers. The interconnection between VDR/VD3 signaling and ΔNp63α, led us to examine whether VDR/VD3 signaling promotes keratinocyte...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Retinoids in leukemia and cellular processes
Share to Vitamin D Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26068789
DOI: 10.1038/cddis.2015.148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

1α, 25-Dihydroxyvitamin D3 and the vitamin D receptor regulates ΔNp63α levels and keratinocyte proliferationPMID 26068789Read ↗

Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivoSemantic proximity Read ↗

An update on vitamin D signaling and cancerSemantic proximity Read ↗

Regulation of VDR by ΔNp63α is associated with inhibition of cell invasionSemantic proximity Read ↗

Anticancer Activity of Vitamin D, Lumisterol and Selected Derivatives against Human Malignant Melanoma Cell LinesSemantic proximity Read ↗

Knocking out the Vitamin D Receptor Enhances Malignancy and Decreases Responsiveness to Vitamin D3 Hydroxyderivatives in Human Melanoma CellsSemantic proximity Read ↗

Novel p63 target genes involved in paracrine signaling and keratinocyte differentiationSemantic proximity Read ↗

ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in Non-Melanoma Skin CancersSemantic proximity Read ↗

Regulation of Gene Expression by 1α,25-Dihydroxyvitamin D<sub>3</sub>and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma CellsSemantic proximity Read ↗

Vitamin D(3) receptor ablation sensitizes skin to chemically induced tumorigenesis.Semantic proximity Read ↗

Vitamin D and cancer: an update of in vitro and in vivo dataSemantic proximity Read ↗

CYP11A1‑derived vitamin D hydroxyderivatives as candidates for therapy of basal and squamous cell carcinomasSemantic proximity Read ↗

Vitamin D Effects on Cell Differentiation and Stemness in CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.