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Article

Vitamin D and cancer: an update of in vitro and in vivo data

1 Jan 2005

Abstract excerpt

1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3, Calcitriol) is a pleiotropic hormone with anti-proliferative, pro-apoptotic and pro-differentiation effects on numerous cell types, which suggest anti-cancer activity in addition to its classical regulatory action on calcium and phosphate metabolism. 1,25(OH)2D3 exerts its actions mainly via its high affinity receptor VDR through a complex network of genomic...

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PMID: 15970529
DOI: 10.2741/1731

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