Article
Self-Assembly of the Second Transmembrane Domain of hCtr1 in Micelles and Interaction with Silver Ion.
The journal of physical chemistry. B - 2 Jul 2015
Dong Zhe, Wang Yunrui, Wang Chunyu, Xu Haoran, Guan Liping, Li Zhengqiang, Li Fei
Abstract excerpt
Human copper transporter 1 (hCtr1) transports copper and silver by a homotrimer. The protein contains three transmembrane domains in which the second transmembrane domain (TMD2) is a key component lining the central pore of the trimer. The MXXXM motif in the C-terminal end of TMD2 plays a significant role in the function of hCtr1. In this study, we characterized the structure and assembly of isolated TMD2 of...
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