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Article

Molecular spectrum of PIK3CA gene mutations in patients with nonsmall-cell lung cancer in Turkey.

Genetic testing and molecular biomarkers - 1 Jul 2015

Ekinci Sadiye, Ilgin-Ruhi Hatice, Dogan Mutlu, Gursoy Semin, Dizbay-Sak Serpil, Demirkazik Ahmet, Tukun Ajlan

Abstract excerpt

AIMS: The aim of the present study was to obtain the first data for the phosphatidylinositol-4,5-bisphosphate 3-kinase (PIK3CA) mutation frequency among nonsmall-cell lung cancer (NSCLC) patients in Turkey. All exons of the PIK3CA gene were investigated by sequence analysis in 40 NSCLC tumor tissue samples. RESULTS: The 1634A>C mutation, which has previously been identified in many cancers including NSCLC, was...

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PMID: 26053643
DOI: 10.1089/gtmb.2015.0060

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