Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

doi:10.1038/nn.4040

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Article

Polygenic risk scores for schizophrenia and bipolar disorder predict creativity.

Nature neuroscience - 1 Jul 2015

Power Robert A, Steinberg Stacy, Bjornsdottir Gyda, Rietveld Cornelius A, Abdellaoui Abdel, Nivard Michel M, Johannesson Magnus, Galesloot Tessel E, Hottenga Jouke J, Willemsen Gonneke, Cesarini David, Benjamin Daniel J, Magnusson Patrik K E, Ullén Fredrik, Tiemeier Henning, Hofman Albert, van Rooij Frank J A, Walters G Bragi, Sigurdsson Engilbert, Thorgeirsson Thorgeir E, Ingason Andres, Helgason Agnar, Kong Augustine, Kiemeney Lambertus A, Koellinger Philipp, Boomsma Dorret I, Gudbjartsson Daniel, Stefansson Hreinn, Stefansson Kari

Abstract excerpt

We tested whether polygenic risk scores for schizophrenia and bipolar disorder would predict creativity. Higher scores were associated with artistic society membership or creative profession in both Icelandic (P = 5.2 × 10(-6) and 3.8 × 10(-6) for schizophrenia and bipolar disorder scores, respectively) and replication cohorts (P = 0.0021 and 0.00086). This could not be accounted for by increased relatedness...

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PMID: 26053403
DOI: 10.1038/nn.4040

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