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Article

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer.

Investigative ophthalmology & visual science - 3 May 2021

Foster James W, Parikh Rupin N, Wang Jiangxia, Bower Kraig S, Matthaei Mario, Chakravarti Shukti, Jun Albert S, Eberhart Charles G, Soiberman Uri S

Abstract excerpt

Purpose: To identify global gene expression changes in the corneal epithelium of keratoconus (KC) patients compared to non-KC myopic controls. Methods: RNA-sequencing was performed on corneal epithelium samples of five progressive KC and five myopic control patients. Selected results were validated using TaqMan quantitative PCR (qPCR) on 31 additional independent samples, and protein level validation was...

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Identifiers

PMID: 33988693
DOI: 10.1167/iovs.62.6.16
PMCID: PMC8132000

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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