Article
Danazol Inhibits Cytochrome P450 2J2 Activity in a Substrate-independent Manner.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2015
Lee Eunyoung, Wu Zhexue, Shon Jong Cheol, Liu Kwang-Hyeon
Abstract excerpt
Cytochrome P450 2J2 (CYP2J2) is an enzyme responsible for the metabolism of endogenous substrates including arachidonic acid, as well as therapeutic drugs such as albendazole, astemizole, ebastine, and terfenadine. Selective inhibitors of CYP2J2 are essential for P450 reaction phenotyping studies. To find representative CYP2J2 index inhibitors, we evaluated the inhibitory potential of danazol, hydroxyebastine,...
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