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Article

A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice.

Molecular cancer therapeutics - 1 Jun 2016

Feng Jia-Hua, Nakagawa-Goto Kyoko, Lee Kuo-Hsiung, Shyur Lie-Fen

Abstract excerpt

Acquired resistance to vemurafenib develops through reactivation of RAF/MEK/ERK signaling or bypass mechanisms. Recent combination therapies such as a MEK inhibitor combined with vemurafenib show improvement in major clinical end points, but the percentage of patients with adverse toxic events is higher than with vemurafenib monotherapy and most patients ultimately relapse. Therefore, there is an urgent need to...

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Source

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Identifiers

PMID: 27048951
DOI: 10.1158/1535-7163.MCT-15-0973
PMCID: PMC4893919

Genes

BRAF
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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