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Article

Different histopathology but the same clonality: ALK rearrangement in a patient with metastatic non-small-cell lung cancer.

International journal of clinical and experimental pathology - 1 Jan 2015

Zhao Jing, Zhou Jianya, Chen Zhen, Wang Bo, Zhang Xiuming, Zhou Jianying, Ding Wei

Abstract excerpt

EML4-ALK rearrangement is detected in 2% to 7% of lung adenocarcinomas, these tumors are sensitive to crizotinib. The histologic feature of ALK translocated non-small-cell lung cancer (NSCLC) has been studied, presence of signet-ring cells was a powerful histologic indicator of ALK rearrangement, and this characteristic histology was present both in primary sites and metastases. However, the case we discribed...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26045865
PMCID: PMC4440174

Genes

ALK
EGFR
EML4
KRAS
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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