Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Different histopathology but the same clonality: ALK rearrangement in a patient with metastatic non-small-cell lung cancer.

International journal of clinical and experimental pathology - 1 Jan 2015

Zhao Jing, Zhou Jianya, Chen Zhen, Wang Bo, Zhang Xiuming, Zhou Jianying, Ding Wei

Abstract excerpt

EML4-ALK rearrangement is detected in 2% to 7% of lung adenocarcinomas, these tumors are sensitive to crizotinib. The histologic feature of ALK translocated non-small-cell lung cancer (NSCLC) has been studied, presence of signet-ring cells was a powerful histologic indicator of ALK rearrangement,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung
Share to Anaplastic Lymphoma Kinase
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to In Situ Hybridization, Fluorescence

Share to Protein-Tyrosine Kinases

Share to Receptor Protein-Tyrosine Kinases

Share to Tomography, X-Ray Computed

Source

Open in PubMed Open full text

Identifiers

PMID: 26045865
PMCID: PMC4440174

Genes

ALK
EGFR
EML4
KRAS
ROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26045865-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Different histopathology but the same clonality: ALK rearrangement in a patient with metastatic non-small-cell lung cancer.PMID 26045865Read ↗

Clonally-related primary ALK rearranged adenocarcinoma and associated metastatic lesions.Semantic proximity Read ↗

Bridging the gap between tumor evolution and clonality diagnostics in multiple lung carcinomas.Semantic proximity Read ↗

[Non-small Cell Lung Cancer with Metachronous Mutations of EGFR and ALK Genes: A Case Report and Literature Review].Semantic proximity Read ↗

Clonality of multifocal nonsmall cell lung cancer: implications for staging and therapy.Semantic proximity Read ↗

New aspects of the clinicopathology and genetic profile of metachronous multiple lung cancers.Semantic proximity Read ↗

Concomitant EML4-ALK rearrangement and EGFR mutation in non-small cell lung cancer patients: a literature review of 100 casesSemantic proximity Read ↗

Use of epidermal growth factor receptor/Kirsten rat sarcoma 2 viral oncogene homolog mutation testing to define clonal relationships among multiple lung adenocarcinomas: comparison with clinical guidelines.Semantic proximity Read ↗

A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype.Semantic proximity Read ↗

Lung adenocarcinoma with concurrent KRAS mutation and ALK rearrangement responding to crizotinib: case report.Semantic proximity Read ↗

An odd dancing couple. Non-small cell lung carcinoma with coexisting EGFR mutation and NTRK-1 translocation: A case report.Semantic proximity Read ↗

Clinicopathology and genetic profile of synchronous multiple small adenocarcinomas: implication for surgical treatment of an uncommon lung malignancy.Semantic proximity Read ↗

Clinically significant sub-clonality for common drivers can be detected in 26% of KRAS/EGFR mutated lung adenocarcinomas.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.