A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype.

doi:10.1371/journal.pone.0076999

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

A comprehensive comparative analysis of the histomorphological features of ALK-rearranged lung adenocarcinoma based on driver oncogene mutations: frequent expression of epithelial-mesenchymal transition markers than other genotype.

PloS one - 1 Jan 2013

Kim Hyojin, Jang Se Jin, Chung Doo Hyun, Yoo Seol Bong, Sun Pingli, Jin Yan, Nam Kyung Han, Paik Jin-Ho, Chung Jin-Haeng

Abstract excerpt

Molecular classification of lung cancer correlates well with histomorphological features. However, specific histomorphological features that differentiate anaplastic lymphoma kinase (ALK)-rearranged tumors from ALK-negative tumors have not been fully evaluated. Eighty ALK-rearranged and 213 ALK-negative (91 epidermal growth factor receptor-mutated; 29 K-ras-mutated; 93 triple-negative) resected lung...

Topics

Adenocarcinoma
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
Analysis of Variance
Anaplastic Lymphoma Kinase
Epithelial-Mesenchymal Transition
Female
Genes, erbB-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, ras

Histological Techniques

Humans

Immunohistochemistry

Lung Neoplasms

Male

Middle Aged

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 24194854
DOI: 10.1371/journal.pone.0076999
PMCID: PMC3806726

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.