Article
Optineurin deficiency in mice contributes to impaired cytokine secretion and neutrophil recruitment in bacteria-driven colitis.
Disease models & mechanisms - 1 Aug 2015
Chew Thean S, O'Shea Nuala R, Sewell Gavin W, Oehlers Stefan H, Mulvey Claire M, Crosier Philip S, Godovac-Zimmermann Jasminka, Bloom Stuart L, Smith Andrew M, Segal Anthony W
Abstract excerpt
Crohn's disease (CD) is associated with delayed neutrophil recruitment and bacterial clearance at sites of acute inflammation as a result of impaired secretion of proinflammatory cytokines by macrophages. To investigate the impaired cytokine secretion and confirm our previous findings, we performed transcriptomic analysis in macrophages and identified a subgroup of individuals with CD who had low expression of...
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