Article
Modulation of human valve interstitial cell phenotype and function using a fibroblast growth factor 2 formulation.
PloS one - 1 Jan 2015
Latif Najma, Quillon Alfred, Sarathchandra Padmini, McCormack Ann, Lozanoski Alec, Yacoub Magdi H, Chester Adrian H
Abstract excerpt
Valve interstitial cells (VICs) are fibroblastic in nature however in culture it is widely accepted that they differentiate into a myofibroblastic phenotype. This study assessed a fibroblast culture media formulation for its ability to maintain the phenotype and function of VICs as in the intact healthy valve. Normal human VICs were cultured separately in standard DMEM and in fibroblast media consisting of FGF2...
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