Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Animal Models for Progressive Multifocal Leukoencephalopathy.

Journal of cellular physiology - 1 Dec 2015

White Martyn K, Gordon Jennifer, Berger Joseph R, Khalili Kamel

Abstract excerpt

Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the CNS caused by the human polyomavirus JC (JCV). JCV replication occurs only in human cells and investigation of PML has been severely hampered by the lack of an animal model. The common feature of PML is impairment of the immune system. The key to understanding PML is working out the complex mechanisms that underlie viral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Brain
Share to Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JC Virus

Share to Leukoencephalopathy, Progressive Multifocal

Share to Myelin Sheath

Share to Species Specificity

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 26041694
DOI: 10.1002/jcp.25047
PMCID: PMC4549183

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Animal Models for Progressive Multifocal Leukoencephalopathy.PMID 26041694Read ↗

Pathogenesis of Progressive Multifocal Leukoencephalopathy—RevisitedSemantic proximity Read ↗

Progressive Multifocal Leukoencephalopathy: Molecular Biology, Pathogenesis and Clinical ImpactSemantic proximity Read ↗

Progressive Multifocal LeukoencephalopathySemantic proximity Read ↗

Progressive Multifocal Leukoencephalopathy: Endemic Viruses and Lethal Brain DiseaseSemantic proximity Read ↗

[New trends in progressive multifocal leukoencephalopathy].Semantic proximity Read ↗

Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger diseaseSemantic proximity Read ↗

Potential Mechanisms of the Human Polyomavirus JC in Neural OncogenesisSemantic proximity Read ↗

Human demyelinating disease and the polyomavirus JCVSemantic proximity Read ↗

Live long and persist: polyomavirus immune evasion in the brain and kidneySemantic proximity Read ↗

Viral mouse models used to study multiple sclerosis: past and presentSemantic proximity Read ↗

Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating diseaseSemantic proximity Read ↗

The human JC polyomavirus (JCPyV): virological background and clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.