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Article

High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.

Plant biotechnology journal - 1 Feb 2016

Madeira Luisa M, Szeto Tim H, Henquet Maurice, Raven Nicole, Runions John, Huddleston Jon, Garrard Ian, Drake Pascal M W, Ma Julian K-C

Abstract excerpt

Rhizosecretion of recombinant pharmaceuticals from in vitro hydroponic transgenic plant cultures is a simple, low cost, reproducible and controllable production method. Here, we demonstrate the application and adaptation of this manufacturing platform to a human antivitronectin IgG1 monoclonal antibody (mAb) called M12. The rationale for specific growth medium additives was established by phenotypic analysis of...

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Identifiers

PMID: 26038982
DOI: 10.1111/pbi.12407
PMCID: PMC11388865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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