Article
Targeting dsRNA-specific single-chain Fv antibody fragments to different cellular locations in Nicotiana tabacum L.
Acta biologica Hungarica - 1 Jun 2006
Morgun B, Richter A, Deshmukh S D, Stepanyuk V, Kálai Katalin, Nagy G, Hufnagel L, Lukács Noémi
Abstract excerpt
Expression of antibodies or antibody fragments in plants is a useful tool for producing active antibody derivatives for diagnostic or pharmaceutical purposes as well as for immunomodulation. We investigated the effect of cellular expression site on the stability and yield of double-stranded RNA (dsRNA)-specific single-chain Fv-fragments (scFv) in transgenic tobacco. Two antibodies (J2 and P6) belonging to the...
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