Article
Improved virus neutralization by plant-produced anti-HIV antibodies with a homogeneous beta1,4-galactosylated N-glycan profile.
The Journal of biological chemistry - 31 Jul 2009
Strasser Richard, Castilho Alexandra, Stadlmann Johannes, Kunert Renate, Quendler Heribert, Gattinger Pia, Jez Jakub, Rademacher Thomas, Altmann Friedrich, Mach Lukas, Steinkellner Herta
Abstract excerpt
It is well established that proper N-glycosylation significantly influences the efficacy of monoclonal antibodies (mAbs). However, the specific immunological relevance of individual mAb-associated N-glycan structures is currently largely unknown, because of the heterogeneous N-glycan profiles of mAbs when produced in mammalian cells. Here we report on the generation of a plant-based expression platform allowing...
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