Article

The Contribution of Baseline Circulating Endocannabinoids to Individual Differences in Human Pain Sensitivity: A Quantitative Sensory Testing Study

2025-08-27

Abstract excerpt

<h4>ABSTRACT</h4> The endocannabinoid (eCB) system—comprising cannabinoid receptors, eCBs (anandamide— AEA, 2-arachidonoylglycerol—2-AG) and related N -acylethanolamines (NAEs; N- palmitoylethanolamide—PEA, and N- oleoylethanolamide—OEA), and metabolizing enzymes (e.g., fatty acid amide hydrolase; FAAH)—modulates nociceptive circuits in rodents. In humans, the FAAH C385A polymorphism is associated with reduce...

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Literature Corpus work: cd74bd6c-1f16-50ee-8988-6b3b7ea6a15a
DOI: 10.1101/2025.08.22.671762

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