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Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice

2 Jun 2015

Abstract excerpt

The curry spice curcumin plays a protective role in mouse models of neurodegenerative diseases, and can also directly modulate aggregation of α-synuclein protein in vitro, yet no studies have described the interaction of curcumin and α-synuclein in genetic synucleinopathy mouse models. Here we examined the effect of chronic and acute curcumin treatment in the Syn-GFP mouse line, which overexpresses wild-type...

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PMID: 26035833
DOI: 10.1371/journal.pone.0128510

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