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Molecular nexopathies: a new paradigm of neurodegenerative disease

19 Jul 2013

Abstract excerpt

Neural networks provide candidate substrates for the spread of proteinopathies causing neurodegeneration, and emerging data suggest that macroscopic signatures of network disintegration differentiate diseases. However, how do protein abnormalities produce network signatures? The answer may lie with 'molecular nexopathies': specific, coherent conjunctions of pathogenic protein and intrinsic network characteristics...

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PMID: 23876425
DOI: 10.1016/j.tins.2013.06.007

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