Article
Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens.
Internal medicine (Tokyo, Japan) - 1 Jan 2015
Okada Kazuya, Kunitomi Akane, Sakai Kazuya, Muranushi Hiroyuki, Okamoto Yusuke, Tsukamoto Taku, Sugiura Hiroyuki, Matsui Hiroyuki, Jo Tomoyasu, Ueda Tomoaki, Onishi Tatsuhito, Ide Masaru, Kimura Shinya, Notohara Kenji, Ueda Yasunori
Abstract excerpt
A 47-year-old woman with pancytopenia, excessive systemic lymphadenopathy and splenomegaly was referred to our hospital. The peripheral blood (PB) smear findings indicated neutropenia with lymphoid cells exhibiting hairy projections, while the histological findings of the cervical lymph node (LN) suggested hairy cell leukemia (HCL). In addition, the BRAF V600E mutation was detected, and the immunoglobulin gene...
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