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Article

The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels.

Scientific reports - 29 May 2015

Chen Yi-An, Peng Yi-Jheng, Hu Meng-Chun, Huang Jing-Jia, Chien Yun-Chia, Wu June-Tai, Chen Tsung-Yu, Tang Chih-Yung

Abstract excerpt

Voltage-gated CLC-1 chloride channels play a critical role in controlling the membrane excitability of skeletal muscles. Mutations in human CLC-1 channels have been linked to the hereditary muscle disorder myotonia congenita. We have previously demonstrated that disease-associated CLC-1 A531V mutant protein may fail to pass the endoplasmic reticulum quality control system and display enhanced protein degradation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26021757
DOI: 10.1038/srep10667
PMCID: PMC4448132

Genes

CLC
DDB1
CRBN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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