Article
Ubiquitin C-terminal hydrolase-L1 protects cystic fibrosis transmembrane conductance regulator from early stages of proteasomal degradation.
The Journal of biological chemistry - 9 Apr 2010
Henderson Mark J, Vij Neeraj, Zeitlin Pamela L
Abstract excerpt
DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) degradation involves ubiquitin modification and efficient proteasomal targeting of the nascent misfolded protein. We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly expressed in cystic fibrosis (CF) airway epithelial cells in vitro and in vivo. We hypothesized that the elevation in UCH-L1 in CF cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.