Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop.

FEBS letters - 14 Feb 2005

Wächter Andrea, Schwappach Blanche

Abstract excerpt

CLC chloride channels are a family of channel proteins mediating chloride transport across the plasma membrane and intracellular membranes. The single yeast CLC protein Gef1p is localized to the Golgi and endosomal system. Investigating epitope-tagged variants of Gef1p, we found that the channel is proteolytically processed in the secretory pathway. Proteolytic cleavage occurs in the first extracellular loop of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Membrane
Share to Chloride Channels
Share to Furin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proprotein Convertases

Share to Protein Processing, Post-Translational

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Sequence Alignment

Source

Identifiers

PMID: 15710404
DOI: 10.1016/j.febslet.2005.01.011

Genes

CLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop.PMID 15710404Read ↗

Introduction of Kex2 cleavage sites in fusion proteins for monitoring localization and transport in yeast secretory pathway.Semantic proximity Read ↗

Amazing chloride channels: an overview.Semantic proximity Read ↗

The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface.Semantic proximity Read ↗

The functioning of mammalian ClC-2 chloride channel in Saccharomyces cerevisiae cells requires an increased level of Kha1p.Semantic proximity Read ↗

Identification of a crosstalk between ClC-1 C-terminal CBS domains and the transmembrane region.Semantic proximity Read ↗

ClC chloride channels in epithelia: recent progress and remaining puzzles.Semantic proximity Read ↗

[Function of the CLC chloride channels and their implication in human pathology].Semantic proximity Read ↗

Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels.Semantic proximity Read ↗

Regulated degradation of KCC2, a potassium-chloride co-transporter required for synaptic transmission and neurodevelopment.Semantic proximity Read ↗

Proteomic interaction profiling reveals KIFC1 as a factor involved in early targeting of F508del-CFTR to degradation.Semantic proximity Read ↗

Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeationSemantic proximity Read ↗

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.