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Article

Clinical and genetic risk factors for epirubicin-induced cardiac toxicity in early breast cancer patients.

Breast cancer research and treatment - 1 Jul 2015

Vulsteke Christof, Pfeil Alena M, Maggen Charlotte, Schwenkglenks Matthias, Pettengell Ruth, Szucs Thomas D, Lambrechts Diether, Dieudonné Anne-Sophie, Hatse Sigrid, Neven Patrick, Paridaens Robert, Wildiers Hans

Abstract excerpt

Anthracycline-induced cardiotoxicity (ACT) is a well-known serious adverse drug reaction leading to substantial morbidity. The purpose of this study was to assess ACT occurrence and clinical and genetic risk factors in early breast cancer patients. In 6 genes of interest (ABCC1, ABCC2, CYBA, NCF4, RAC2, SLC28A3), 10 single nucleotide polymorphisms (SNPs) involved in ACT were selected based on a literature search....

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Source

Identifiers

PMID: 26017071
DOI: 10.1007/s10549-015-3437-9

Genes

ABCC1
ABCC2
CYBA
NCF4
RAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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