Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation ( TET ) family, TET 1, in scleroderma fibroblasts

25 May 2015

Abstract excerpt

The precise mechanisms of tissue fibrosis have not yet been elucidated in systemic sclerosis (SSc). However, studies of the regulation of DNA methylation, the most widely studied epigenetic mechanism, have confirmed the involvement of the TET family proteins, recently identified DNA demethylases, in the pathogenesis of SSc. The mRNA levels of TET family members were compared in normal and SSc fibroblasts. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting
Share to Systemic Sclerosis and Related Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26013976
DOI: 10.1111/exd.12767

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global DNA hypomethylation and hypoxia‐induced expression of the ten eleven translocation ( TET ) family, TET 1, in scleroderma fibroblastsPMID 26013976Read ↗

Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype.Semantic proximity Read ↗

Hypomethylation and overexpression of ITGAL (CD11a) in CD4+ T cells in systemic sclerosisSemantic proximity Read ↗

Histone Deacetylase 5 Is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repression of Proangiogenic FactorsSemantic proximity Read ↗

Epigenetic suppression of Fli1, a potential predisposing factor in the pathogenesis of systemic sclerosis.Semantic proximity Read ↗

Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype.Semantic proximity Read ↗

Association of hypoxia-inducible factor 1A (HIF1A) gene polymorphisms with systemic sclerosis in a French European Caucasian population.Semantic proximity Read ↗

Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosisSemantic proximity Read ↗

Long non-coding RNA HOTAIR induces GLI2 expression through Notch signalling in systemic sclerosis dermal fibroblastsSemantic proximity Read ↗

Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms.Semantic proximity Read ↗

Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH.Semantic proximity Read ↗

Increased frequency of in vivo hprt gene-mutated T cells in the peripheral blood of patients with systemic sclerosis.Semantic proximity Read ↗

Inhibition of EZH2 prevents fibrosis and restores normal angiogenesis in sclerodermaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.