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Article

53 BP 1 suppresses epithelial–mesenchymal transition by downregulating ZEB 1 through micro RNA ‐200b/429 in breast cancer

25 May 2015

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is an important mechanism of cancer invasion and metastasis. Although p53 binding protein 1 (53BP1) has been implicated in several biological processes, its function in EMT of human cancers has not yet been reported. Here, we show that 53BP1 negatively regulated EMT by modulating ZEB1 through targeting microRNA (miR)-200b and miR-429. Furthermore, 53BP1 promoted...

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PMID: 26011542
DOI: 10.1111/cas.12699

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