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Transfer of penicillin resistance from S treptococcus oralis to S treptococcus pneumoniae identifies mur E as resistance determinant

26 May 2015

Abstract excerpt

Beta-lactam resistant clinical isolates of Streptococcus pneumoniae contain altered penicillin-binding protein (PBP) genes and occasionally an altered murM, presumably products of interspecies gene transfer. MurM and MurN are responsible for the synthesis of branched lipid II, substrate for the PBP catalyzed transpeptidation reaction. Here we used the high-level beta-lactam resistant S. oralis Uo5 as donor in...

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PMID: 26010014
DOI: 10.1111/mmi.13070

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