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Article

Combinations of PBPs and MurM protein variants in early and contemporary high-level penicillin-resistant Streptococcus pneumoniae isolates in Spain.

The Journal of antimicrobial chemotherapy - 1 May 2006

del Campo Rosa, Cafini Fabio, Morosini María Isabel, Fenoll Asunción, Liñares Josefina, Alou Luis, Sevillano David, Cantón Rafael, Prieto José, Baquero Fernando

Abstract excerpt

OBJECTIVES: High-level penicillin resistance in Streptococcus pneumoniae requires extensive re-modulation of the penicillin-binding proteins (PBPs), and murM gene function is also required for the expression of resistance. In this work, we determined whether specific changes in PBPs were associated with specific MurM variants. METHODS: Two collections of highly penicillin-resistant (MIC 2-8 mg/L) isolates,...

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PMID: 16533824
DOI: 10.1093/jac/dkl083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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