Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillation

25 May 2015

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate pacemaker currents in the atrium. The microRNA (miR) families miR-1 and miR-133 regulate the expression of multiple genes involved in myocardial function, including HCN channels. It was hypothesized that age‑dependent changes in HCN2, HCN4, miR‑1 and miR‑133 expression may contribute to age‑associated atrial fibrillation, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Atrial Fibrillation Management and Outcomes
Share to Cardiac electrophysiology and arrhythmias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26005035
DOI: 10.3892/mmr.2015.3831

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Altered expression of hyperpolarization-activated cyclic nucleotide-gated channels and microRNA-1 and -133 in patients with age-associated atrial fibrillationPMID 26005035Read ↗

Updates on HCN Channels in the Heart: Function, Dysfunction and Pharmacology.Semantic proximity Read ↗

Ageing-dependent remodelling of ion channel and Ca<sup>2+</sup>clock genes underlying sino-atrial node pacemakingSemantic proximity Read ↗

MiR-1 alleviates chronic heart failure through HCN2/HCN4 axis in vitroSemantic proximity Read ↗

HCN channels and heart rate.Semantic proximity Read ↗

Pacemaker activity of the human sinoatrial node: effects of HCN4 mutations on the hyperpolarization-activated current.Semantic proximity Read ↗

Decreased Left Atrial Cardiomyocyte FGF13 Expression Increases Vulnerability to Postoperative Atrial Fibrillation in HumansSemantic proximity Read ↗

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse ModelsSemantic proximity Read ↗

Atrial arrhythmogenicity in aged Scn5a+/DeltaKPQ mice modeling long QT type 3 syndrome and its relationship to Na+ channel expression and cardiac conduction.Semantic proximity Read ↗

MicroRNA-328 Contributes to Adverse Electrical Remodeling in Atrial FibrillationSemantic proximity Read ↗

HCN4 Gene Polymorphisms Are Associated With Occurrence of Tachycardia-Induced Cardiomyopathy in Patients With Atrial FibrillationSemantic proximity Read ↗

Ion channel gene changes with inflammageingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.