Structural basis for encapsidation of genomic RNA by La Crosse Orthobunyavirus nucleoprotein

Abstract excerpt

The nucleoprotein (NP) of segmented negative-strand RNA viruses such as Orthomyxo-, Arena-, and Bunyaviruses coats the genomic viral RNA and together with the polymerase forms ribonucleoprotein particles (RNPs), which are both the template for replication and transcription and are packaged into new virions. Here we describe the crystal structure of La Crosse Orthobunyavirus NP both RNA free and a tetrameric form...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Study of Mite Species
• Share to Vector-Borne Animal Diseases
• Share to Viral Infections and Vectors