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Lack of relationship between the P413L chromogranin B variant and a SALS Italian cohort.

Gene - 1 Sept 2015

Ricci Claudia, Claudia Ricci, Battistini Stefania, Stefania Battistini, Avemaria Francesca, Francesca Avemaria, Benigni Michele, Michele Benigni, Tarlarini Claudia, Claudia Tarlarini, Giannini Fabio, Fabio Giannini, Corbo Massimo, Massimo Corbo, Lunetta Christian, Christian Lunetta, Penco Silvana, Silvana Penco

Abstract excerpt

Chromogranins were reported to interact specifically with mutant forms of superoxide dismutase that are linked to amyotrophic lateral sclerosis (ALS). Particularly, a variation c.1238C>T (p.Pro413Leu) in the chromogranin B gene, CHGB, has been associated with an earlier age at onset in both familial and sporadic ALS in French/French-Canadian populations studied. The aim of our study was to evaluate the P413L...

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PMID: 26003296
DOI: 10.1016/j.gene.2015.05.040

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CHGB

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