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Article

No association of the SOD1 locus and disease susceptibility or phenotype in sporadic ALS.

Neurology - 28 Dec 2004

Broom W J, Parton M J, Vance C A, Russ C, Andersen P M, Hansen V, Leigh P N, Powell J F, Al-Chalabi A, Shaw C E

Abstract excerpt

Mutations in the copper zinc superoxide dismutase gene (SOD1) are found in 20% of familial and 3% of sporadic ALS patients. SOD1 protein aggregation can be detected in motor neurons of mutation-negative sporadic cases but a pathogenic role for wild-type SOD1 in ALS has not been demonstrated. In this study of 233 ALS cases and 248 controls the authors found no significant association between four individual single...

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Share to Amyotrophic Lateral Sclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Restriction Fragment Length

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Source

Identifiers

PMID: 15623718
DOI: 10.1212/01.wnl.0000147264.60349.eb

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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